The best way to stop variants is to stop the spread of the disease. And the best way to stop the spread is vaccination. Low vaccination coverage is what increases the chances that even more concerning variants could emerge. Over the years, several diseases have been eliminated that thanks to vaccines. These include polio, small pox, measles, rubella, tetanus, diphtheria. If we all work together, get vaccinated and use smart prevention strategies, one can hope that we can add COVID-19 to this list.